OPTIMIZATION, FORMULATION AND CHARACTERIZATION OF NANO BASED TDDS OF EPLERENONE

Objective: The proposed work was aimed to formulation, characterization and optimization of transdermal patches nanoparticles eplerenone for efficient delivery the drug. Methods: Eplerenone were formulated by casting evaporation method. Transdermal made using combinations hydroxypropyl methylcellulose (HPMC), Eudragit RS 100. Physical evaluation (organoleptic properties, pH, weight uniformity, thickness percent moisture content, tensile strength) then performed. permeation into skin evaluated Franz diffusion cell. Results: could be method with ranged from 0.10±0.11 mm 0.15±0.54 mm. average 4 cm2 350±0.202 mg 386±0.527 mg, content 1.0 6.0%. Folding endurance prepared in range 355±0.20 368±0.20. Prepared batches NS1 NS9 percentage uptake loss as well pH measurement. result vitro drug release study batch containing 30 %/cm 2/h 87.74 % released 16 h. Conclusion: All met requirement physical patch.